The Suzuki-Miyaura reaction - the coupling an arylboronic acid or ester with an arylhalide or pseudo-halide has gained widespread acceptance as one of the key methods of choice for the synthesis of biaryl and hetero-biaryl systems. It has a number of distinct advantages over other metal-catalysed cross-coupling reactions, due to the broad array of functionality tolerated and the non-toxic nature of the inorganic by-products. Boronic acids or esters are the reagents of choice for this powerful C-C bond forming reaction.
Boron Molecular has built on the initial discovery of Suzuki and Miyaura through the development of a broad platform of technologies and improvements that enable the synthesis of an impressive range of organoboronic acids and esters, and their subsequent use in coupling reactions. Typically, the need to protect and deprotect sensitive funtionality is minimized thereby facilitating the synthesis of complex molecules.
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